However, before they did the whole, "Oh, Ban, Himiko and you are related," I was all for a Ban/Himiko pairing. Way to piss me off Ayamine-sensei. Well, should that be Aoki-sensei I should be blaming?
ROFL, if your reaction was bad, it really can't compare to Ban's face when HE found out they were related.
Anyway, back on topic: my absolute, total favorite pairing in this series is Sakura and Makubex. I never saw them as a mother/son or brother/sister relationship; I always saw them, from the moment they first appeared together, as a romantic couple.